Heya. As some may remember, I said I was going to build an E5 machine. 
Well I did, well atleast ordered the most similar to what I wanted, and 
exchanged the graphics-card (pcie3.0) only. I was completely correct in 
that this machine, would have low-jitter
/low-latency. And it completely lives up to expectations. So if you want 
low-jitter (think amiga, if that references means something to you), 
definately get an E5 (with direct i/o).

Threadirqs also works on this computer.

Peace Be With You.