filesystem on mdadm raid from unpartioned block devices

A quick question that I haven't been able to find and answer for.

I have been using whole block devices (whole unpartitioned hard drives)
in various raid 1 and 5 setups using mdadm 3.1.4 with pretty mundane
options (default options such as striping and but using metadata 1.2).
Typically I use mkfs.ext4 with no options (default) to install the
filesystem.

Is there an issue with alignment on the newer 4096-byte drives. If so
what would be the proper approach?

I thank you for your time.

Ashley